Many methods of intradermal hyposensitization with insulin (in fact, immunization with insulin) have been proposed, largely differing in the rate of increasing the intradermal dose of insulin.

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The rate of hyposensitization in the case of severe allergic reactions of the immediate type is determined primarily by the body's response to an increase in the dose of insulin.

  • Sometimes it is suggested to start with very high, almost homeopathic, dilutions (1:100,000, for example).
  • Desensitization techniques used today in the treatment of allergy to human insulin preparations and human insulin analogs have been described for a long time, including in my doctoral dissertation, which presents the results of my treatment of about 50 cases of a severe allergic reaction of an immediate type to all insulin preparations produced at that time.
  • Treatment is extremely burdensome for both the patient and the doctor, sometimes dragging on for several months.
But in the end, it was possible to get rid of severe systemic allergy to insulin in all patients who applied for help. And, finally, how to treat an allergy to insulin, if it is noted for all insulin preparations, and the patient needs insulin urgently for health reasons? If the patient is in a diabetic coma or precoma, then insulin is prescribed in the dose necessary to remove the coma, even intravenously, without any prior desensitization or administration of antihistamines or glucocorticoids.

In the world practice of insulin therapy, four such cases are described, in two of which insulin therapy was carried out despite allergy, and the patients managed to wake up from a coma, and they did not develop an anaphylactic reaction, despite intravenous insulin administration. In two other cases, when doctors refrained from timely administration of insulin, the patients died from a diabetic coma.